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Glee star Cory MonteithCory Monteit, 31,  the “Glee” star who was found dead   in his hotel room at Fairmont Pacific Rim Hotel  in Vancouver, Canada on July 13 shortly after noon was shooting heroin and downing champagne in his hotel room on the night of his death.

The celebrity gossip website TMZ.com, is reporting that the final coroner’s confirms what many had speculated initially.  Monteith’s official cause of death as “mixed drug toxicity, involving intravenous heroin use combined with the ingestion of alcohol.”

At the time of Monteit’s death…responders  who arrived to the scene, discovered a “spoon with drug residue and a used hypodermic needle.”   Along with the drug paraphernalia….they found two empty bottles of champagne.

Cory, who was dating co-star Lea Michele at the time of his death  reportedly “had a history of illicit drug use with intermittent periods of rehabilitation and of abstinence from drugs.”

The coroner suggests that Cory’s tolerance for substance abuse may have been lower than usual because he had stopped using since a rehab stint in April.

Understanding Drug Addiction and Tolerance:

When drugs such as heroin are used repeatedly over time, tolerance may develop. Tolerance occurs when the person no longer Cast of Gleeresponds to the drug in the way that person initially responded. Stated another way, it takes a higher dose of the drug to achieve the same level of response achieved initially. For example, in the case of heroin or morphine, tolerance develops rapidly to the analgesic effects of the drug. The development of tolerance is not addiction, although many drugs that produce tolerance also have addictive potential. Tolerance to drugs can be produced by several different mechanisms, but in the case of morphine or heroin, tolerance develops at the level of the cellular targets. For example, when morphine binds to opiate receptors, it triggers the inhibition of an enzyme (adenylate cyclase) that orchestrates several chemicals in the cell to maintain the firing of impulses. After repeated activation of the opiate receptor by morphine, the enzyme adapts so that the morphine can no longer cause changes in cell firing. Thus, the effect of a given dose of morphine or heroin is diminished.

More about Cory Monteit Next Page

Cory, who was dating co-star Lea Michele at the time of his death Cory Allan Michael Monteith (May 11, 1982 – July 13, 2013) was a Canadian actor and musician, best known for his role as Finn Hudson on the Fox television series Glee. Born in Calgary, Alberta, Canada, and raised in Victoria, British Columbia, Canada, Monteith had a troubled adolescence involving substance abuse from age 12, and he left school at 16. After an intervention by family and friends, he entered drug rehabilitation at age 19.

 

As an actor based in British Columbia, he had minor roles on television series before an audition tape of him singing “Can’t Fight This Feeling” helped to land him the biggest role of his career, Finn on Glee. Following his success on Glee, Monteith’s film work included the movie Monte Carlo and a starring role in Sisters & Brothers. In a 2011 interview with Parade magazine, he discussed his history of substance abuse as a teen, and in March 2013, he again sought treatment for addiction. On July 13 2013, he died of a toxic combination of heroin and alcohol in a Vancouver hotel room.

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